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BDBM50003485 CHEMBL134143::[1-(3,3-Diphenyl-propionyl)-piperidin-4-ylidene]-pyridin-3-yl-acetonitrile; hydrate

SMILES: O=[#6](-[#6]-[#6](-c1ccccc1)-c1ccccc1)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\C#N)-c1cccnc1

InChI Key: InChIKey=JSIZGZYXULERFB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003485   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003485
PNG
(CHEMBL134143 | [1-(3,3-Diphenyl-propionyl)-piperid...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCC(CC1)=C(C#N)c1cccnc1
Show InChI InChI=1S/C27H25N3O/c28-19-26(24-12-7-15-29-20-24)23-13-16-30(17-14-23)27(31)18-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-12,15,20,25H,13-14,16-18H2
MMDB

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Article
PubMed
n/an/a 26n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair