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BDBM50003496 CHEMBL133425::Pyridin-3-yl-{4-[2-(3,4,5-trimethoxy-phenyl)-acetyl]-piperazin-1-yl}-acetonitrile; hydrate

SMILES: COc1cc(CC(=O)N2CCN(CC2)C(C#N)c2cccnc2)cc(OC)c1OC

InChI Key: InChIKey=NOLGXOUXQLBOEQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003496   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003496
PNG
(CHEMBL133425 | Pyridin-3-yl-{4-[2-(3,4,5-trimethox...)
Show SMILES COc1cc(CC(=O)N2CCN(CC2)C(C#N)c2cccnc2)cc(OC)c1OC
Show InChI InChI=1S/C22H26N4O4/c1-28-19-11-16(12-20(29-2)22(19)30-3)13-21(27)26-9-7-25(8-10-26)18(14-23)17-5-4-6-24-15-17/h4-6,11-12,15,18H,7-10,13H2,1-3H3
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Article
PubMed
n/an/a 460n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair