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BDBM50003502 CHEMBL3215754::CHEMBL545304::[4-(Naphthalene-2-carbonyl)-piperazin-1-yl]-pyridin-3-yl-acetonitrile; dihydrochloride

SMILES: O=C(N1CCN(CC1)C(C#N)c1cccnc1)c1ccc2ccccc2c1

InChI Key: InChIKey=HNLYUBHKEYFILB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003502   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003502
PNG
(CHEMBL3215754 | CHEMBL545304 | [4-(Naphthalene-2-c...)
Show SMILES O=C(N1CCN(CC1)C(C#N)c1cccnc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H20N4O/c23-15-21(20-6-3-9-24-16-20)25-10-12-26(13-11-25)22(27)19-8-7-17-4-1-2-5-18(17)14-19/h1-9,14,16,21H,10-13H2
MMDB

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PC cid
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Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair