BindingDB logo
myBDB logout

BDBM50003509 CHEMBL335556::[4-(4-Phenyl-butyryl)-piperazin-1-yl]-pyridin-3-yl-acetonitrile; hydrate

SMILES: O=C(CCCc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1

InChI Key: InChIKey=XUGDESZYKGRZPP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003509   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003509
PNG
(CHEMBL335556 | [4-(4-Phenyl-butyryl)-piperazin-1-y...)
Show SMILES O=C(CCCc1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C21H24N4O/c22-16-20(19-9-5-11-23-17-19)24-12-14-25(15-13-24)21(26)10-4-8-18-6-2-1-3-7-18/h1-3,5-7,9,11,17,20H,4,8,10,12-15H2
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 260n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair