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BDBM50003511 (4-{2-[Methyl-(1-phenyl-ethyl)-amino]-acetyl}-piperazin-1-yl)-pyridin-3-yl-acetonitrile; trihydrochloride; hydrate::CHEMBL545306

SMILES: CC(N(C)CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1

InChI Key: InChIKey=IZXCGAMMMZSBAE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003511   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003511
PNG
((4-{2-[Methyl-(1-phenyl-ethyl)-amino]-acetyl}-pipe...)
Show SMILES CC(N(C)CC(=O)N1CCN(CC1)C(C#N)c1cccnc1)c1ccccc1
Show InChI InChI=1S/C22H27N5O/c1-18(19-7-4-3-5-8-19)25(2)17-22(28)27-13-11-26(12-14-27)21(15-23)20-9-6-10-24-16-20/h3-10,16,18,21H,11-14,17H2,1-2H3
MMDB

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Similars

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair