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BDBM50003512 CHEMBL133964::[4-(2,4-Diphenyl-butyryl)-piperazin-1-yl]-pyridin-3-yl-acetonitrile

SMILES: O=C(C(CCc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1

InChI Key: InChIKey=KNNTZDWZRCXKKM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003512   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003512
PNG
(CHEMBL133964 | [4-(2,4-Diphenyl-butyryl)-piperazin...)
Show SMILES O=C(C(CCc1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Show InChI InChI=1S/C27H28N4O/c28-20-26(24-12-7-15-29-21-24)30-16-18-31(19-17-30)27(32)25(23-10-5-2-6-11-23)14-13-22-8-3-1-4-9-22/h1-12,15,21,25-26H,13-14,16-19H2
MMDB

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Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair