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BDBM50003558 CHEMBL3216867::CHEMBL555357::[4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-pyridin-4-yl-acetonitrile; dihydrochloride

SMILES: O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1ccncc1

InChI Key: InChIKey=OCUHBVDILXASAC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003558   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Cavia porcellus)
BDBM50003558
PNG
(CHEMBL3216867 | CHEMBL555357 | [4-(3,3-Diphenyl-pr...)
Show SMILES O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1ccncc1
Show InChI InChI=1S/C26H26N4O/c27-20-25(23-11-13-28-14-12-23)29-15-17-30(18-16-29)26(31)19-24(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-14,24-25H,15-19H2
MMDB

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Similars

Article
PubMed
n/an/a 51n/an/an/an/an/an/a



J. Uriach& C£a.S.A.

Curated by ChEMBL


Assay Description
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.


J Med Chem 35: 4118-34 (1992)


Article DOI: 10.1021/jm00100a018
BindingDB Entry DOI: 10.7270/Q228087F
More data for this
Ligand-Target Pair