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BDBM50003830 6-[4,5-Bis-(3-chloro-phenyl)-1H-imidazol-2-ylsulfanylmethyl]-4-hydroxy-4-methyl-tetrahydro-pyran-2-one::CHEMBL336696

SMILES: C[C@]1(O)CC(CSc2nc(c([nH]2)-c2cccc(Cl)c2)-c2cccc(Cl)c2)OC(=O)C1

InChI Key: InChIKey=RBXCQNKCHSOBEQ-UGNFMNBCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50003830   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)
BDBM50003830
PNG
(6-[4,5-Bis-(3-chloro-phenyl)-1H-imidazol-2-ylsulfa...)
Show SMILES C[C@]1(O)CC(CSc2nc(c([nH]2)-c2cccc(Cl)c2)-c2cccc(Cl)c2)OC(=O)C1
Show InChI InChI=1S/C22H20Cl2N2O3S/c1-22(28)10-17(29-18(27)11-22)12-30-21-25-19(13-4-2-6-15(23)8-13)20(26-21)14-5-3-7-16(24)9-14/h2-9,17,28H,10-12H2,1H3,(H,25,26)/t17?,22-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Rhone-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome


J Med Chem 35: 4384-92 (1992)


Article DOI: 10.1021/jm00101a016
BindingDB Entry DOI: 10.7270/Q218374H
More data for this
Ligand-Target Pair