BDBM50004205 MK-045::MK-0457::TOZASERTIB::US9249124, VX680::VX-68::VX-680

SMILES: CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1

InChI Key: InChIKey=GCIKSSRWRFVXBI-UHFFFAOYSA-N

Data: 24 KI  41 IC50  10 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 82 hits for monomerid = 50004205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase C (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.4	18
TBA									Citation and Details
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase C (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	241	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase C (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	261	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	453	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mouse)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.501	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase C (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	208	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Mouse)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase A (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Aurora kinase B (Human)	BDBM50004205 (MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	148	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair