BDBM50004679 2-Benzyl-naphthalen-1-ol::2-Benzyl-naphthalen-1-ol(DuP 654)::CHEMBL85000

SMILES Oc1c(Cc2ccccc2)ccc2ccccc12

InChI Key InChIKey=CZTSOXCSVFEFIK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50004679   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity of the compound against 5-lipoxygenase of RBL-1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity of the compound against phospholipase A2 of Croatalus adamanteusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Bos taurus)
E.I. Du Pont De Nemours

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50:  3.40E+3nMAssay Description:In vitro inhibition of Prostaglandin G/H synthase in BSV cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50:  19nMAssay Description:Inhibition of 5-lipoxygenase in Rattus norvegicus Rat basophil leukemia cells (RBL) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50:  19nMAssay Description:Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50:  19nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Bos taurus)
E.I. Du Pont De Nemours

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50: >7.50E+5nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004679(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Affinity DataIC50:  6.90nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed