BDBM50005480 (-)-combretastatin::(Z)-3'-hydroxy-3,4,4',5-tetramethoxystilbene::(Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol::(combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::(combretastin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-Methoxy-5-[(Z)-2-(3,4,5-trimethox y-phenyl)-vinyl]-phenol::2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-methoxy-5-(3,4,5-trimethoxystyryl)phenol::2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol::5-(3,4,5-trimethoxystyryl)-2-methoxyphenol::5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol::CHEMBL67::Combrestatin A-4::Combrestatin A4::Combretastastin A-4::Combretastatin::Combretastatin-A4::Combretastin A-4::Z-Combretastatin A-4::combretastatin A-4, (CSA4)::combretastin A4

SMILES: COc1ccc(cc1O)/C=C\c2cc(c(c(c2)OC)OC)OC

InChI Key: InChIKey=HVXBOLULGPECHP-UHFFFAOYSA-N

Data: 2 KI  103 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 107 hits for monomerid = 50005480   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tubulin polymerization-promoting protein (Human)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin polymerization-promoting protein (Human)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Baker's yeast)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Baker's yeast)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Human)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta-3 chain (Human)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta-2B chain (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta-2B chain (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bovine)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin alpha-1A chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tubulin beta chain (Pig)	BDBM50005480 (combretastin A4 | CHEMBL67 | 2-Methoxy-5-[2-(3,4,5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair