BDBM50005520 (S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propylamino]-benzoylamino}-pentanedioic acid::2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propylamino]-benzoylamino}-pentanedioic acid::CHEMBL13659

SMILES Nc1nc(N)c(CCCNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c(=O)[nH]1

InChI Key InChIKey=CPVRCGLCOADOPV-ZDUSSCGKSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50005520   

TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  1.90E+3nMAssay Description:Triglutamyl homologue inhibition activity against AICAR formyltransferase was determined against L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  3.00E+3nMAssay Description:Ability to inhibit glycinamide ribonucleotide transformylase (GAR-Tfase) in vitro, using hog liver with (6R)-10-formyl-FH4 as cofactorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  9.40E+4nMAssay Description:In vitro inhibitory activity of the compound against MOLT-4 T-cell leukemia cell AICAR transformylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  9.40E+4nMAssay Description:Inhibition activity against AICAR formyltransferase determined against MOLT-4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  700nMAssay Description:Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition activity against AICAR formyltransferase determined against MOLT-4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  700nMAssay Description:Inhibition activity against Glycinamide ribonucleotide transformylase(GAR-TFase) against hog liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition activity against AICAR formyltransferase determined against MOLT-4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  3.00E+3nMAssay Description:In vitro inhibition of hog liver GAR transformylase with (6R)-10-formyl-FH4 as cofactorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed