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BDBM50005734 2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propylamino]-3-methoxy-benzoylamino}-pentanedioic acid::CHEMBL29713

SMILES: COc1cc(ccc1NCCCc1c(N)nc(N)[nH]c1=O)C(=O)NC(CCC(O)=O)C(O)=O

InChI Key: InChIKey=FZVNPRJLVNYBCI-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50005734   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycinamide ribonucleotide formyltransferase (GARFTase)


(Homo sapiens (Human))
BDBM50005734
PNG
(2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5...)
Show SMILES COc1cc(ccc1NCCCc1c(N)nc(N)[nH]c1=O)C(=O)NC(CCC(O)=O)C(O)=O
Show InChI InChI=1S/C20H26N6O7/c1-33-14-9-10(17(29)24-13(19(31)32)6-7-15(27)28)4-5-12(14)23-8-2-3-11-16(21)25-20(22)26-18(11)30/h4-5,9,13,23H,2-3,6-8H2,1H3,(H,24,29)(H,27,28)(H,31,32)(H5,21,22,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.87E+4n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of hog liver GAR transformylase with (6R)-10-formyl-FH4 as cofactor


J Med Chem 35: 1399-410 (1992)


Article DOI: 10.1021/jm00086a008
BindingDB Entry DOI: 10.7270/Q20R9NBZ
More data for this
Ligand-Target Pair