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BDBM50006599 1-Methyl-5-[1,2,5]thiadiazol-3-yl-1,2,3,6-tetrahydro-pyridine::CHEMBL74301

SMILES: CN1CCC=C(C1)c1cnsn1

InChI Key: InChIKey=UCJUMFDXIJNLOK-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50006599   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic receptor M1 and M2


(RAT)
BDBM50006599
PNG
(1-Methyl-5-[1,2,5]thiadiazol-3-yl-1,2,3,6-tetrahyd...)
Show SMILES CN1CCC=C(C1)c1cnsn1
Show InChI InChI=1S/C8H11N3S/c1-11-4-2-3-7(6-11)8-5-9-12-10-8/h3,5H,2,4,6H2,1H3
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UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 145n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50006599
PNG
(1-Methyl-5-[1,2,5]thiadiazol-3-yl-1,2,3,6-tetrahyd...)
Show SMILES CN1CCC=C(C1)c1cnsn1
Show InChI InChI=1S/C8H11N3S/c1-11-4-2-3-7(6-11)8-5-9-12-10-8/h3,5H,2,4,6H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Novo Nordisk CNS Division

Curated by ChEMBL


Assay Description
In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligand


J Med Chem 35: 2274-83 (1992)


Article DOI: 10.1021/jm00090a019
BindingDB Entry DOI: 10.7270/Q22J69TH
More data for this
Ligand-Target Pair