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BDBM50007408 4-Phenyl-piperidine::4-phenylpiperidine::CHEMBL2011546::CHEMBL20969

SMILES: C1CC(CCN1)c1ccccc1

InChI Key: InChIKey=UTBULQCHEUWJNV-UHFFFAOYSA-N

Data: 5 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50007408   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(RAT)
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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PubMed
440n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by PDSP Ki Database




Eur J Pharmacol 168: 387-92 (1989)


BindingDB Entry DOI: 10.7270/Q23R0RC5
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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PubMed
1.52E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain


J Med Chem 31: 1968-71 (1988)


Article DOI: 10.1021/jm00118a018
BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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1.98E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes


J Med Chem 34: 3360-5 (1992)


Article DOI: 10.1021/jm00116a003
BindingDB Entry DOI: 10.7270/Q2MC8XZR
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Displacement of [3H]-mesulergine from 5HT2C receptor expressed in CHO cell membranes after 90 mins by scintillation counting


Bioorg Med Chem Lett 22: 2560-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.122
BindingDB Entry DOI: 10.7270/Q2JD4XSQ
More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor


(Homo sapiens (Human))
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells


J Med Chem 39: 4017-26 (1996)


Article DOI: 10.1021/jm9603936
BindingDB Entry DOI: 10.7270/Q23F4NQT
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Homo sapiens)
BDBM50007408
PNG
(4-Phenyl-piperidine | 4-phenylpiperidine | CHEMBL2...)
Show SMILES C1CC(CCN1)c1ccccc1
Show InChI InChI=1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2
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n/an/a 9.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles


J Med Chem 32: 1217-30 (1989)


Article DOI: 10.1021/jm00126a013
BindingDB Entry DOI: 10.7270/Q2TQ60JR
More data for this
Ligand-Target Pair