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BDBM50007457 1-[4-(8,9-Difluoro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-ethanone::CHEMBL342747

SMILES: [#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cc(F)c(F)cc2-[#6]-[#6]-c2cccnc-12

InChI Key: InChIKey=XWJJAWRVPJASIO-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50007457   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(RAT)
BDBM50007457
PNG
(1-[4-(8,9-Difluoro-5,6-dihydro-benzo[5,6]cyclohept...)
Show SMILES CC(=O)N1CCC(CC1)=C1c2cc(F)c(F)cc2CCc2cccnc12
Show InChI InChI=1S/C21H20F2N2O/c1-13(26)25-9-6-14(7-10-25)20-17-12-19(23)18(22)11-16(17)5-4-15-3-2-8-24-21(15)20/h2-3,8,11-12H,4-7,9-10H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.00E+4n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand


J Med Chem 34: 457-61 (1991)


Article DOI: 10.1021/jm00105a069
BindingDB Entry DOI: 10.7270/Q2BV7FK0
More data for this
Ligand-Target Pair
Platelet activating factor receptor


(HUMAN)
BDBM50007457
PNG
(1-[4-(8,9-Difluoro-5,6-dihydro-benzo[5,6]cyclohept...)
Show SMILES CC(=O)N1CCC(CC1)=C1c2cc(F)c(F)cc2CCc2cccnc12
Show InChI InChI=1S/C21H20F2N2O/c1-13(26)25-9-6-14(7-10-25)20-17-12-19(23)18(22)11-16(17)5-4-15-3-2-8-24-21(15)20/h2-3,8,11-12H,4-7,9-10H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when ch...


J Med Chem 34: 457-61 (1991)


Article DOI: 10.1021/jm00105a069
BindingDB Entry DOI: 10.7270/Q2BV7FK0
More data for this
Ligand-Target Pair