BDBM50008072 (+)-pilocarpine::(3S,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one::(3S,4R)-3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone::(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone::CHEMBL550::ISOPTO CARPINE::PILOCARPINE::PILOCARPINE HYDROCHLORIDE

SMILES: CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI Key: InChIKey=QCHFTSOMWOSFHM-UHFFFAOYSA-N

Data: 18 KI  7 IC50  4 Kd  5 EC50

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50008072   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2A13 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2A6 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.69E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.69E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	832	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Mouse)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	6.30E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	8.79E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		83	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		1.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		1.11E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2A13 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor DM1 (Fruit fly)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor DM1 (Fruit fly)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		2.98E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 2A6 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		3.67E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		6.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		9.93E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Rat)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Human)	BDBM50008072 ((3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5...) Show SMILES Show InChI	GoogleScholar	UniChem		1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair