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BDBM50008454 CHEMBL142704::{4-Oxo-3-[(2-trifluoromethyl-phenylcarbamoyl)-methyl]-3,4-dihydro-phthalazin-1-yl}-acetic acid

SMILES: OC(=O)Cc1nn(CC(=O)Nc2ccccc2C(F)(F)F)c(=O)c2ccccc12

InChI Key: InChIKey=DXOXELZVCCBSPL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50008454   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50008454
PNG
(CHEMBL142704 | {4-Oxo-3-[(2-trifluoromethyl-phenyl...)
Show SMILES OC(=O)Cc1nn(CC(=O)Nc2ccccc2C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C19H14F3N3O4/c20-19(21,22)13-7-3-4-8-14(13)23-16(26)10-25-18(29)12-6-2-1-5-11(12)15(24-25)9-17(27)28/h1-8H,9-10H2,(H,23,26)(H,27,28)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.90E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against aldose reductase isolated from human placenta


J Med Chem 35: 457-65 (1992)


Article DOI: 10.1021/jm00081a006
BindingDB Entry DOI: 10.7270/Q28051K1
More data for this
Ligand-Target Pair