BDBM50008923 (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione::(S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin)::4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin)::4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT)::4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione::CHEMBL65::Camptothecin (CT)::US20240246941, Compound SJ000285410::camptothecine::cid_24360

SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O

InChI Key: InChIKey=VSJKWCGYPAHWDS-UHFFFAOYSA-N

Data: 60 IC50  1 Kd  6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 67 hits for monomerid = 50008923   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 2-alpha (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Type II restriction enzyme PstI (Providencia stuartii)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Type II restriction enzyme HindIII (Haemophilus influenzae (strain ATCC 51907 / DSM 11...)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Type II restriction enzyme EcoRI (Escherichia coli)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Type II restriction enzyme BamHI (Bacillus amyloliquefaciens)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA ligase (Enterobacteria phage T4)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Deoxyribonuclease-2-alpha (Pig)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Deoxyribonuclease-1 (Bovine)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ribonuclease pancreatic (Bovine)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Type II restriction enzyme ScaI (Streptomyces caespitosus)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Green monkey)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Mouse)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase (Bovine)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus type 1)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Somatostatin receptor type 1/2/3/4/5 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Topoisomerase I subunit B (Leishmania major)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	670	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Heterogeneous nuclear ribonucleoprotein A1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	82.7	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus type 1)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.74E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	679	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 3 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Melanoma-associated antigen E1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.50E+5	n/a	n/a	n/a	n/a	7.8	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	7.8	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Human)	BDBM50008923 (4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair