BDBM50008935 (20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::(4-Ethyl-4,9-dihydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-10-ylmethyl)-dimethyl-ammonium::(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3'',4'':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE::(S)-10-dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::(S)-11-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione::10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Topotecan)::10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione(Topotecan)::10-dimethylaminomethyl-4-ethyl-4,9-dihydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3'',4'':6,7]indolizino[1,2-b]quinoline-3,14-dione::CHEMBL84::Hycamtin::TOPOTECAN::TOPOTECAN HYDROCHLORIDE::cid_60700

SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O

InChI Key: InChIKey=UCFGDBYHRUNTLO-UHFFFAOYSA-N

Data: 22 IC50  1 Kd  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50008935   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 2 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Multidrug and toxin extrusion protein 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Multidrug and toxin extrusion protein 2 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	71.3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Mouse)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha/2-beta (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 2-alpha/2-beta (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha (Human)	BDBM50008935 (CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	71	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair