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BDBM50008990 1,2-Dihydro-indazol-3-one::1H-indazol-3-ol::CHEMBL276725

SMILES: O=c1[nH][nH]c2ccccc12

InChI Key: InChIKey=SWEICGMKXPNXNU-UHFFFAOYSA-N

Data: 5 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50008990   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nitric oxide synthase, brain


(Homo sapiens (Human))
BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
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n/an/a>1.00E+6n/an/an/an/an/an/a



UNED

Curated by ChEMBL


Assay Description
Inhibition of recombinant NOS1 assessed as citrulline formation


Bioorg Med Chem 17: 6180-7 (2009)


Article DOI: 10.1016/j.bmc.2009.07.067
BindingDB Entry DOI: 10.7270/Q2ZG6SBD
More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Rattus norvegicus (rat))
BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
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n/an/a>1.00E+6n/an/an/an/an/an/a



UNED

Curated by ChEMBL


Assay Description
Inhibition of nNOS in LPS-stimulated Wistar rat striata assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by liquid scintillati...


Eur J Med Chem 46: 1439-47 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.027
BindingDB Entry DOI: 10.7270/Q2891659
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
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n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
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n/an/a 700n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 (LT) production in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Cyclooxygenase


(RAT)
BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
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n/an/a 3.00E+4n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
PDB
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair