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BDBM50009008 2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one::CHEMBL268738::CHEMBL3144716

SMILES: O=c1n(Cc2ccco2)[nH]c2ccccc12

InChI Key: InChIKey=FFYKZUMLEJLSIN-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50009008   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50009008
PNG
(2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(Cc2ccco2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2O2/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 270n/an/an/an/an/an/a



ICI Pharmaceuticals Group

Curated by ChEMBL


Assay Description
In vitro inhibition of LTB4 production was measured in rat blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50009008
PNG
(2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(Cc2ccco2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2O2/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 15n/an/an/an/a



ICI Pharmaceuticals Group

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Cyclooxygenase


(RAT)
BDBM50009008
PNG
(2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(Cc2ccco2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2O2/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



ICI Pharmaceuticals Group

Curated by ChEMBL


Assay Description
In vitro inhibition of PGE-2 production was measured in rat blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair