BDBM50009860 2-(6-Methoxy-naphthalen-2-yl)-propionic acid::2-(6-Methoxy-naphthalen-2-yl)-propionic acid(naproxen)::2-(6-methoxy-2-naphthyl)propanoic acid::2-(6-methoxynaphthalen-2-yl)propanoic acid::CHEMBL154::Naproxen::Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid

SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O

InChI Key InChIKey=CMWTZPSULFXXJA-UHFFFAOYSA-N

Data  5 KI  10 IC50

PDB links: 10 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50009860   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataKi:  9.30E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
TargetHormone-sensitive lipase(Rattus norvegicus (Rat))
University Of Jordan

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  2.43E+4nMAssay Description:Compound was tested in vitro for inhibition of human umbilical cord endothelial cells(ECV-304 cell line) Prostaglandin G/H synthase 2 at 10 microMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) using tyrosine 4 as substrate by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Guangzhou Institutes Of Biomedicine And Health

Curated by ChEMBL
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Ovine COX-1 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  350nMAssay Description:Compound was tested in vitro for inhibition of human platelet Prostaglandin G/H synthase 1 at 10 microMMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50009860(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair