BDBM50010044 2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide::2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide (Fenanserin)::2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide(Fananserin)::CHEMBL83894::ChEMBL_131689::FANANSERIN

SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1

InChI Key InChIKey=VGIGHGMPMUCLIQ-UHFFFAOYSA-N

Data  12 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50010044   

Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Cracow University Of Technology

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat cortical membranes incubated for 15 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to rat cerebral cortex homogenate 5-HT2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  0.260nMAssay Description:Binding constant against 5-hydroxytryptamine 2 receptor (in vivo)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  25nMAssay Description:Binding constant against histamine H1 receptor (in vivo)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  38nMAssay Description:Binding affinity to rat cerebral cortex homogenate alpha 1 adrenergic receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  38nMAssay Description:Binding constant against Alpha-1 adrenergic receptor (in vivo)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  70nMAssay Description:Binding constant against 5-hydroxytryptamine 1A receptor (in vivo)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat hippocampal membranes preincubated for 5 mins followed by addition of [3H]-8-OHDPAT and mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  200nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding constant against dopamine receptor D2 (in vivo)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatal membranes incubated for 40 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: >1.00E+3nMAssay Description:The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50:  0.5nMAssay Description:The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50010044(2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50:  103nMAssay Description:The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed