BDBM50010044 2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide::2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide (Fenanserin)::2-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide(Fananserin)::CHEMBL83894::ChEMBL_131689::FANANSERIN
SMILES Fc1ccc(cc1)N1CCN(CCCN2c3cccc4cccc(c34)S2(=O)=O)CC1
InChI Key InChIKey=VGIGHGMPMUCLIQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50010044
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Cracow University Of Technology
Curated by ChEMBL
Cracow University Of Technology
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor in rat cortical membranes incubated for 15 mins by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Binding affinity to rat cerebral cortex homogenate 5-HT2 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Binding constant against 5-hydroxytryptamine 2 receptor (in vivo)More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Binding constant against histamine H1 receptor (in vivo)More data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Beijing Normal University
Curated by ChEMBL
Beijing Normal University
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Binding affinity to rat cerebral cortex homogenate alpha 1 adrenergic receptor assessed as inhibition constantMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Binding constant against Alpha-1 adrenergic receptor (in vivo)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 70nMAssay Description:Binding constant against 5-hydroxytryptamine 1A receptor (in vivo)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 70nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat hippocampal membranes preincubated for 5 mins followed by addition of [3H]-8-OHDPAT and mea...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Displacement of [3H]-dofetilide to HEK cells stably expressing hERG voltage-gated IKr potassium channel Kv11.1More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Binding constant against dopamine receptor D2 (in vivo)More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in Sprague-Dawley rat striatal membranes incubated for 40 minsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:The concentration required to inhibit [3H]spiperone binding to dopamine receptor D2 in rat brain membranes (in vitro)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:The concentration required to inhibit [3H]ketanserin binding to 5-hydroxytryptamine 2 receptor in rat brain membranes (in vitro)More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Centre De Recherches De Vitry Alfortville Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)More data for this Ligand-Target Pair