BDBM50010132 (3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin-1-yl)-chroman-6-carbonitrile::1-((3S,4R)-6-Ethynyl-3-hydroxy-2,2-dimethyl-chroman-4-yl)-pyrrolidin-2-one::3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin-1-yl)-chroman-6-carbonitrile::3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin-1-yl)-chroman-6-carbonitrile (Lemakalim)::3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin-1-yl)-chroman-6-carbonitrile(BRL 38227)::3S,4R-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin-1-yl)-chroman-6-carbonitrile::BRL-38227::CHEMBL100::Levcromakalim

SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N1CCCC1=O)C#N

InChI Key InChIKey=TVZCRIROJQEVOT-CABCVRRESA-N

Data  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50010132   

TargetATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial(Bos taurus)
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50010132((3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory concentration towards rat mitochondrial F1F0 ATP hydrolase using a pyruvate kinase / lactate dehydrogenase systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50010132((3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Affinity DataIC50:  3.53E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 9(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50010132((3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Affinity DataEC50:  1.25E+3nMAssay Description:Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPRMore data for this Ligand-Target Pair