BDBM50010462 CHEBI:78825::CHEMBL3264002::US11147816, RO5126766-(CH5126766)::US11701360, R05126766::US11964950, Compound Ref-5::US20230270730, Compound ref-5::US20230382863, Compound avutometinib::US20240327355, Compound ref-5

SMILES: CC1=C(C(=O)Oc2c1ccc(c2)Oc3ncccn3)Cc4ccnc(c4F)NS(=O)(=O)NC

InChI Key: InChIKey=LMMJFBMMJUMSJS-UHFFFAOYSA-N

Data: 17 IC50  1 Kd

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50010462   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity mitogen-activated protein kinase kinase 1 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity mitogen-activated protein kinase kinase 1 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Dual specificity mitogen-activated protein kinase kinase 1 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	292	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 1 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	292	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 1 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	292	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.22	n/a	n/a	n/a	n/a	n/a
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Dual specificity mitogen-activated protein kinase kinase 1/2 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50010462 (CHEMBL3264002 | CHEBI:78825 | US11147816, RO512676...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair