BDBM50010936 2-{4-[(4-Amino-2-methyl-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid::CHEMBL307137

SMILES Cc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cnc2n1

InChI Key InChIKey=XOSWZVVCHBBRAM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50010936   

TargetDihydrofolate reductase(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50010936(2-{4-[(4-Amino-2-methyl-pteridin-6-ylmethyl)-amino...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound was evaluated for Dihydrofolate Reductase (DHFR) inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50010936(2-{4-[(4-Amino-2-methyl-pteridin-6-ylmethyl)-amino...)
Affinity DataIC50: >5.00E+4nMAssay Description:Compound was tested for its inhibitory activity against dihydrofolate reductase (DHFR), isolated from MTX-resistant WI-L2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed