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BDBM50011424 2-(4-Hydroxy-3,5-dimethoxy-phenyl)-chromen-4-one::2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-chromen-4-one::3',5'-dimethoxy-4'-hydroxyflavone::4'-Hydroxy-3',5'-dimethoxyflavone::CHEMBL354496

SMILES: COc1cc(cc(OC)c1O)-c1cc(=O)c2ccccc2o1

InChI Key: InChIKey=KFLJXWFYZQGKAQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50011424   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (human))
BDBM50011424
PNG
(2-(4-Hydroxy-3,5-dimethoxy-phenyl)-chromen-4-one |...)
Show SMILES COc1cc(cc(OC)c1O)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C17H14O5/c1-20-15-7-10(8-16(21-2)17(15)19)14-9-12(18)11-5-3-4-6-13(11)22-14/h3-9,19H,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of p56 lck


J Nat Prod 55: 1529-1560 (1992)


Article DOI: 10.1021/np50089a001
BindingDB Entry DOI: 10.7270/Q2J966CC
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (human))
BDBM50011424
PNG
(2-(4-Hydroxy-3,5-dimethoxy-phenyl)-chromen-4-one |...)
Show SMILES COc1cc(cc(OC)c1O)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C17H14O5/c1-20-15-7-10(8-16(21-2)17(15)19)14-9-12(18)11-5-3-4-6-13(11)22-14/h3-9,19H,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Ability to inhibit protein-tyrosine kinase activity of p56lck (isolated from bovine thymus) in vitro.


J Med Chem 34: 798-806 (1991)


Article DOI: 10.1021/jm00106a047
BindingDB Entry DOI: 10.7270/Q2CF9P3J
More data for this
Ligand-Target Pair