BDBM50014324 5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine::5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine(LY56110)::CHEMBL29669::LY-56110

SMILES: Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1

InChI Key: InChIKey=FOQIAMHLCXUKND-UHFFFAOYSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50014324   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 19A1 (Rattus norvegicus)	BDBM50014324 (5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[B...) Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1 Show InChI InChI=1S/C17H12Cl2N2/c18-15-5-1-12(2-6-15)17(14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,17H	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University School of Medicine Curated by ChEMBL					Assay Description Binding affinity for Cytochrome P450 19A1				J Med Chem 33: 2933-42 (1990) Article DOI: 10.1021/jm00173a001 BindingDB Entry DOI: 10.7270/Q2VM4CW9
					More data for this Ligand-Target Pair
Cytochrome P450 19A1 (Rattus norvegicus)	BDBM50014324 (5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[B...) Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1 Show InChI InChI=1S/C17H12Cl2N2/c18-15-5-1-12(2-6-15)17(14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,17H	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.				J Med Chem 30: 1359-65 (1987) Article DOI: 10.1021/jm00391a016 BindingDB Entry DOI: 10.7270/Q2NP251P
					More data for this Ligand-Target Pair
Cytochrome P450 19A1 (Rattus norvegicus)	BDBM50014324 (5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[B...) Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1 Show InChI InChI=1S/C17H12Cl2N2/c18-15-5-1-12(2-6-15)17(14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,17H	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome				J Med Chem 33: 416-29 (1990) Article DOI: 10.1021/jm00163a065 BindingDB Entry DOI: 10.7270/Q2WM1F0N
					More data for this Ligand-Target Pair