Found 3 hits for monomerid = 50014412 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50014412
 (PIMASERTIB | Pimasertib | US11147816, Pimasertib (...)Show InChI InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar
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MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 in human COLO205 cells |
Bioorg Med Chem Lett 24: 2555-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.086 BindingDB Entry DOI: 10.7270/Q2PG1T73 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
VHL-MAP2K1/MAP2K2
(Homo sapiens (Human)) | BDBM50014412
 (PIMASERTIB | Pimasertib | US11147816, Pimasertib (...)Show InChI InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB US Patent
| n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GENUV Inc.
US Patent
| Assay Description The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31]. |
US Patent US11147816 (2021)
|
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50014412
 (PIMASERTIB | Pimasertib | US11147816, Pimasertib (...)Show InChI InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) |
Bioorg Med Chem Lett 24: 2555-9 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.086 BindingDB Entry DOI: 10.7270/Q2PG1T73 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |