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BDBM50014804 Bis-(4-chloro-phenyl)-isothiazol-5-yl-methanol::CHEMBL132708

SMILES: OC(c1ccns1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key: InChIKey=ODIXSVXECWIULF-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50014804   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014804
PNG
(Bis-(4-chloro-phenyl)-isothiazol-5-yl-methanol | C...)
Show SMILES OC(c1ccns1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H11Cl2NOS/c17-13-5-1-11(2-6-13)16(20,15-9-10-19-21-15)12-3-7-14(18)8-4-12/h1-10,20H
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Article
PubMed
n/an/an/an/a 19n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)


Article DOI: 10.1021/jm00163a065
BindingDB Entry DOI: 10.7270/Q2WM1F0N
More data for this
Ligand-Target Pair