BDBM50015009 CHEMBL3262367::US9259422, 7a, R = 3,5-diMePh- BU10100::US9480684, 7a, R = 3,5- diMePh- BU10100

SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@]([H])(C1)[C@](C)(O)c1cc(C)cc(C)c1)ccc3O

InChI Key InChIKey=JMCOUXKMURIBCQ-VTRXWXBFSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50015009   

TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015009(CHEMBL3262367 | US9259422, 7a, R = 3,5-diMePh- BU1...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]diprenorphine from recombinant human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015009(CHEMBL3262367 | US9259422, 7a, R = 3,5-diMePh- BU1...)
Affinity DataKi:  0.100nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015009(CHEMBL3262367 | US9259422, 7a, R = 3,5-diMePh- BU1...)
Affinity DataKi:  0.100nM ΔG°:  -13.6kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015009(CHEMBL3262367 | US9259422, 7a, R = 3,5-diMePh- BU1...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015009(CHEMBL3262367 | US9259422, 7a, R = 3,5-diMePh- BU1...)
Affinity DataKi:  0.280nM ΔG°:  -13.0kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015009(CHEMBL3262367 | US9259422, 7a, R = 3,5-diMePh- BU1...)
Affinity DataKi:  0.280nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent