BDBM50015088 (E)-N-Hydroxy-3-phenyl-acrylamide::(E)-N-Hydroxy-3-phenylacrylamide::CHEMBL154574::N-Hydroxy-3-phenyl-acrylamide::US10188756, Compound CN86::trans-N-Hydroxy-3-phenyl-acrylamide

SMILES ONC(=O)\C=C\c1ccccc1

InChI Key InChIKey=UVDDFTZLVFIQFL-VOTSOKGWSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50015088   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50: >5.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  1.95E+4nMT: 2°CAssay Description:Inhibition of HDAC4 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  457nMT: 2°CAssay Description:Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  759nMT: 2°CAssay Description:Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  22nMT: 2°CAssay Description:Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  133nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  470nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 3(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  151nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50: >1.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50: >1.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  21.7nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 7(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50: >2.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  725nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibitory activity against RBL-1 5-LOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed