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BDBM50015444 CHEMBL3265028

SMILES: COc1cccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)c1

InChI Key: InChIKey=IJUGKHZKAQRCJD-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50015444   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015444
PNG
(CHEMBL3265028)
Show SMILES COc1cccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)c1
Show InChI InChI=1S/C20H16N6O/c1-27-16-4-2-3-15(10-16)23-19-20-21-7-8-26(20)12-18(24-19)13-5-6-14-11-22-25-17(14)9-13/h2-12H,1H3,(H,22,25)(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 374n/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of Syk in antihuman IgM-stimulated human Ramos cells assessed as decrease in BCR-mediated BLNK phosphorylation by cellular assay


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015444
PNG
(CHEMBL3265028)
Show SMILES COc1cccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)c1
Show InChI InChI=1S/C20H16N6O/c1-27-16-4-2-3-15(10-16)23-19-20-21-7-8-26(20)12-18(24-19)13-5-6-14-11-22-25-17(14)9-13/h2-12H,1H3,(H,22,25)(H,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.5n/an/an/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair