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BDBM50016895 5-Methoxy-1-propyl-2,3,10,10a-tetrahydro-1H-9-oxa-1-aza-phenanthrene::CHEMBL349824

SMILES: CCCN1CCC=C2C1COc1cccc(OC)c21

InChI Key: InChIKey=DUCWFBXYQNVRNF-UHFFFAOYSA-N

Data: 4 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50016895   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50016895
PNG
(5-Methoxy-1-propyl-2,3,10,10a-tetrahydro-1H-9-oxa-...)
Show SMILES CCCN1CCC=C2C1COc1cccc(OC)c21
Show InChI InChI=1S/C16H21NO2/c1-3-9-17-10-5-6-12-13(17)11-19-15-8-4-7-14(18-2)16(12)15/h4,6-8,13H,3,5,9-11H2,1-2H3
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Article
PubMed
n/an/a 1.32E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Concentration of the compound necessary to achieve half maximal inhibition of [125I]- Iodocyanopindolol, binds to 5-hydroxytryptamine 1B receptor at ...


J Med Chem 32: 720-7 (1989)


Article DOI: 10.1021/jm00123a039
BindingDB Entry DOI: 10.7270/Q2639NQ6
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50016895
PNG
(5-Methoxy-1-propyl-2,3,10,10a-tetrahydro-1H-9-oxa-...)
Show SMILES CCCN1CCC=C2C1COc1cccc(OC)c21
Show InChI InChI=1S/C16H21NO2/c1-3-9-17-10-5-6-12-13(17)11-19-15-8-4-7-14(18-2)16(12)15/h4,6-8,13H,3,5,9-11H2,1-2H3
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PubMed
n/an/a 839n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Concentration necessary to achieve half maximal inhibition of [3H]ketanserin, binds to 5-hydroxytryptamine 2 receptor at 1 uM


J Med Chem 32: 720-7 (1989)


Article DOI: 10.1021/jm00123a039
BindingDB Entry DOI: 10.7270/Q2639NQ6
More data for this
Ligand-Target Pair
adrenergic Alpha2


(BOVINE)
BDBM50016895
PNG
(5-Methoxy-1-propyl-2,3,10,10a-tetrahydro-1H-9-oxa-...)
Show SMILES CCCN1CCC=C2C1COc1cccc(OC)c21
Show InChI InChI=1S/C16H21NO2/c1-3-9-17-10-5-6-12-13(17)11-19-15-8-4-7-14(18-2)16(12)15/h4,6-8,13H,3,5,9-11H2,1-2H3
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PubMed
n/an/a 151n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Concentration necessary to achieve half maximal inhibition of [3H]-clonidine binding to alpha-2 adrenergic receptor at 1 uM


J Med Chem 32: 720-7 (1989)


Article DOI: 10.1021/jm00123a039
BindingDB Entry DOI: 10.7270/Q2639NQ6
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50016895
PNG
(5-Methoxy-1-propyl-2,3,10,10a-tetrahydro-1H-9-oxa-...)
Show SMILES CCCN1CCC=C2C1COc1cccc(OC)c21
Show InChI InChI=1S/C16H21NO2/c1-3-9-17-10-5-6-12-13(17)11-19-15-8-4-7-14(18-2)16(12)15/h4,6-8,13H,3,5,9-11H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.80n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Concentration necessary to achieve half maximal inhibition of [3H]-8-Hydroxy-2-(di-n-propylamino)tetralin binding to 5-hydroxytryptamine 1A receptor ...


J Med Chem 32: 720-7 (1989)


Article DOI: 10.1021/jm00123a039
BindingDB Entry DOI: 10.7270/Q2639NQ6
More data for this
Ligand-Target Pair