BDBM50017181 CHEMBL441738
SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
InChI Key InChIKey=UAHFGYDRQSXQEB-LEBBXHLNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 105 hits for monomerid = 50017181
Affinity DataKi: 0.0460nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC1 receptor expressed in BHK570 cells after 90 mins in presence of ovalbuminMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from MC4 receptor after 2 hrs by gamma counting in presence of ovalbuminMore data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor human MC5 expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Displacement of [125I]-NAD-alpha-MSH from human recombinant MC3 receptor expressed in BHK570 cells after 1 hr in presence of ovalbuminMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0880nMAssay Description:Agonist activity at mouse melanocortin-1 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
Affinity DataEC50: 0.330nMAssay Description:Agonist activity at mouse melanocortin-3 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at mouse melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
Affinity DataEC50: 0.260nMAssay Description:Agonist activity at mouse melanocortin-5 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assessed as stim...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Displacement of [I125]-NDP-MSH from wild type human melanocortin-4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0180nMAssay Description:Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0300nMAssay Description:Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.140nMAssay Description:Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity at mouse melanocortin 4 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0460nMAssay Description:Maximal agonist response of mouse melanocortin 1 receptor (MC1R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.290nMAssay Description:Effective concentration for maximum agonist response towards mouse melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Maximal agonist response at rat melanocortin 3 receptor (MC3R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.0640nMAssay Description:Maximum agonist response for mouse melanocortin 5 receptor (MC5R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Effective concentration for intracellular cAMP accumulation in human melanocortin 3 receptor expressing HEK 293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Effective concentration for intracellular cAMP accumulation in human melanocortin 5 receptor expressing HEK 293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Effective concentration for intracellular cAMP accumulation in human melanocortin 4 receptor expressing HEK 293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 4 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 3 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 5 receptor expressed in HEK293 cells; N = 4More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Binding affinity for Human Melanocortin 4 receptor expressed in L-cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.240nMAssay Description:Effective concentration required for intracellular cAMP accumulation against Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Binding affinity for Human Melanocortin 3 receptor expressed in L-cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Effective concentration required for intracellular cAMP accumulation by Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.230nMAssay Description:Effective concentration required for intracellular cAMP accumulation by Melanocortin 5 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.890nMAssay Description:Binding affinity for Human Melanocortin 5 receptor expressed in L-cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0170nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.130nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0230nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 1 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.140nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0920nMAssay Description:Activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.810nMAssay Description:Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human recombinant MC4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.310nMAssay Description:Displacement of 125I-NDP-MSH from mouse MC1R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Displacement of 125I-NDP-MSH from mouse MC3R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Displacement of 125I-NDP-MSH from mouse MC4R expressed in HEK293 cells incubated for 1 hr by gamma counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0300nMAssay Description:Agonist activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.240nMAssay Description:Agonist activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.460nMAssay Description:Agonist activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.310nMAssay Description:Agonist activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation incubated for 2 hrs by alphascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125I]NDP-a-MSH from human recombinant MC4 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataEC50: 0.390nMAssay Description:Agonist activity at mouse MC4R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0150nMAssay Description:Agonist activity at mouse MC1R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0900nMAssay Description:Agonist activity at mouse MC3R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.110nMAssay Description:Agonist activity at mouse MC5R expressed in HEK293 cells assessed as increase in forskolin-induced cAMP accumulation preincubated for 2 hrs followed ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayMore data for this Ligand-Target Pair