BDBM50017244 (R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)propionic acid::2-Amino-3-(4-bromo-3-hydroxy-isoxazol-5-yl)-propionic acid::CHEMBL73698

SMILES NC(Cc1o[nH]c(=O)c1Br)C(O)=O

InChI Key InChIKey=JRTOQOAGTSUNHA-UHFFFAOYSA-N

Data  8 KI  2 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50017244   

TargetGlutamate receptor 1(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataKi:  170nMAssay Description:Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 1 (GluR1) expressed in Sf 9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataKi:  250nMAssay Description:Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 2 (GluR2) expressed in Sf 9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataKi:  4.80E+3nMAssay Description:Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor ionotropic kainate 1 (GluR5) expressed in Sf 9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataKi:  1.17E+4nMAssay Description:Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 4 (GluR4) expressed in Sf 9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataKi:  1.20E+4nMAssay Description:Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 3 (GluR3) expressed in Sf 9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataKi:  3.40E+4nMAssay Description:Binding affinity of compound was determined against N-methyl-D-aspartate glutamate receptor, using radioligand [3H]- CGP-39653More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor ionotropic kainate 6 (GluR6) expressed in Sf 9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataKi:  3.29E+5nMAssay Description:Antagonist activity of compound at Metabotropic glutamate receptor 1 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  2.02E+5nMAssay Description:Agonist activity at recombinant GluA3 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at recombinant GluA1 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  5.40E+3nMAssay Description:Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Mus musculus)
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  1.40E+4nMAssay Description:Effective concentration of compound was determined for electrophysiological properties on Metabotropic glutamate receptor 1 using rat cortical slice ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Rattus norvegicus)
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  5.40E+3nMAssay Description:Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cort...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Rattus norvegicus)
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  3.80E+4nMAssay Description:Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cort...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  2.00E+5nMAssay Description:Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cort...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataIC50:  650nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA receptor, using radioligand [3H]- AMPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataEC50:  2.02E+5nMAssay Description:Agonist activity at recombinant GluA3 receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50017244((R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)pr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity of compound was determined against KA receptor, using radioligand [3H]- KAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed