BDBM50017270 CHEMBL3287725::US10099993, Compound 74

SMILES Cc1c(O)c(ccc1OCCCCOc1cccc(C(O)=O)c1C)C(=O)CC(C)(C)C

InChI Key InChIKey=AXCUOQYTJKESER-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50017270   

TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Sanford-Burnham Medical Research Institute

Curated by ChEMBL
LigandPNGBDBM50017270(CHEMBL3287725 | US10099993, Compound 74)
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017270(CHEMBL3287725 | US10099993, Compound 74)
Affinity DataEC50:  300nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017270(CHEMBL3287725 | US10099993, Compound 74)
Affinity DataEC50:  136nMpH: 7.3 T: 2°CAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM50017270(CHEMBL3287725 | US10099993, Compound 74)
Affinity DataEC50:  136nMAssay Description:Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed