Found 15 hits for monomerid = 50017896 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PCBioAssay
| n/a | n/a | 3.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Research Institute
Curated by PubChem BioAssay
| |
PubChem Bioassay (2016)
BindingDB Entry DOI: 10.7270/Q2CZ35ZF |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against human thromboxane synthetase |
J Med Chem 24: 1139-48 (1982)
Article DOI: 10.1021/jm00142a005 BindingDB Entry DOI: 10.7270/Q2KK9CB6 |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research
Curated by ChEMBL
| Assay Description Inhibition of thromboxane A2 synthetase as reduced ADP-induced aggregation of human platelet rich plasma in the presence of pig aortal microsomes |
J Med Chem 32: 890-7 (1989)
Article DOI: 10.1021/jm00124a027 BindingDB Entry DOI: 10.7270/Q26W993X |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Rattus norvegicus) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Company, Ltd.
Curated by ChEMBL
| Assay Description Tested in vitro against TXA2 synthetase inhibitory activity in rat whole blood |
J Med Chem 36: 4061-8 (1994)
Article DOI: 10.1021/jm00077a009 BindingDB Entry DOI: 10.7270/Q2QJ7GBK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Company, Ltd.
Curated by ChEMBL
| Assay Description Tested in vitro against TXA2 synthetase inhibitory activity in human platelet |
J Med Chem 36: 4061-8 (1994)
Article DOI: 10.1021/jm00077a009 BindingDB Entry DOI: 10.7270/Q2QJ7GBK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Company, Ltd.
Curated by ChEMBL
| Assay Description Tested in vitro against TXA2 synthetase inhibitory activity in human whole blood |
J Med Chem 36: 4061-8 (1994)
Article DOI: 10.1021/jm00077a009 BindingDB Entry DOI: 10.7270/Q2QJ7GBK |
More data for this Ligand-Target Pair | |
Prostanoid TP receptor
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar
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CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia-Farmitalia Carlo Erba
Curated by ChEMBL
| Assay Description In vitro thromboxane-A2 receptor binding affinity to displace by 50% [3H]-SQ 29548 binding from washed human platelets |
J Med Chem 37: 3588-604 (1994)
Article DOI: 10.1021/jm00047a016 BindingDB Entry DOI: 10.7270/Q2C24VFD |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Rattus norvegicus) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia-Farmitalia Carlo Erba
Curated by ChEMBL
| Assay Description In vitro inhibition of thromboxane-A2 synthase in rat whole blood during clotting at 37 degrees centigrade |
J Med Chem 37: 3588-604 (1994)
Article DOI: 10.1021/jm00047a016 BindingDB Entry DOI: 10.7270/Q2C24VFD |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Company, Ltd.
Curated by ChEMBL
| Assay Description Tested in vitro against TXA2 synthetase inhibitory activity in human platelet |
J Med Chem 36: 4061-8 (1994)
Article DOI: 10.1021/jm00077a009 BindingDB Entry DOI: 10.7270/Q2QJ7GBK |
More data for this Ligand-Target Pair | |
Thromboxane-A synthase
(Rattus norvegicus) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Company, Ltd.
Curated by ChEMBL
| Assay Description Tested in vitro against TXA2 synthetase inhibitory activity in rat platelet |
J Med Chem 36: 4061-8 (1994)
Article DOI: 10.1021/jm00077a009 BindingDB Entry DOI: 10.7270/Q2QJ7GBK |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)] |
Bioorg Med Chem Lett 12: 771-4 (2002)
Article DOI: 10.1016/s0960-894x(02)00005-7 BindingDB Entry DOI: 10.7270/Q23X85ZH |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibition of TXB2 production by incubating prostaglandin H2 with human platelet microsomes. |
Bioorg Med Chem Lett 12: 341-4 (2002)
Article DOI: 10.1016/s0960-894x(01)00731-4 BindingDB Entry DOI: 10.7270/Q2ST7P56 |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Nikken Chemicals Co., Ltd.
Curated by ChEMBL
| Assay Description Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomes |
Bioorg Med Chem Lett 12: 1383-6 (2002)
Article DOI: 10.1016/s0960-894x(02)00186-5 BindingDB Entry DOI: 10.7270/Q2MG7NT9 |
More data for this Ligand-Target Pair | |
Thromboxane A2 Synthase (P450 TxA2)
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against Thromboxane A2 synthase in human platelet microsome |
Bioorg Med Chem Lett 5: 1087-1090 (1995)
Article DOI: 10.1016/0960-894X(95)00171-O BindingDB Entry DOI: 10.7270/Q2XG9R3P |
More data for this Ligand-Target Pair | |
Cystic fibrosis transmembrane conductance regulator
(Homo sapiens (Human)) | BDBM50017896
 ((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)Show InChI InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+ | PDB
Reactome pathway
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PCBioAssay
| n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
Southern Research Institute
Curated by PubChem BioAssay
| |
PubChem Bioassay (2016)
BindingDB Entry DOI: 10.7270/Q2CZ35ZF |
More data for this Ligand-Target Pair | |