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BDBM50018219 2-[(2-Benzyl-3-hydroxycarbamoyl-propionyl)-methyl-amino]-3-phenyl-propionic acid::CHEMBL290366

SMILES: CN(C(Cc1ccccc1)C(O)=O)C(=O)C(CC(=O)NO)Cc1ccccc1

InChI Key: InChIKey=GHDOLEQBVCTJMN-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50018219   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50018219
PNG
(2-[(2-Benzyl-3-hydroxycarbamoyl-propionyl)-methyl-...)
Show SMILES CN(C(Cc1ccccc1)C(O)=O)C(=O)C(CC(=O)NO)Cc1ccccc1
Show InChI InChI=1S/C21H24N2O5/c1-23(18(21(26)27)13-16-10-6-3-7-11-16)20(25)17(14-19(24)22-28)12-15-8-4-2-5-9-15/h2-11,17-18,28H,12-14H2,1H3,(H,22,24)(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of Aminopeptidase N activity in pig kidney with 10 nM [3H]-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)


Article DOI: 10.1021/jm00127a017
BindingDB Entry DOI: 10.7270/Q2610Z9F
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50018219
PNG
(2-[(2-Benzyl-3-hydroxycarbamoyl-propionyl)-methyl-...)
Show SMILES CN(C(Cc1ccccc1)C(O)=O)C(=O)C(CC(=O)NO)Cc1ccccc1
Show InChI InChI=1S/C21H24N2O5/c1-23(18(21(26)27)13-16-10-6-3-7-11-16)20(25)17(14-19(24)22-28)12-15-8-4-2-5-9-15/h2-11,17-18,28H,12-14H2,1H3,(H,22,24)(H,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase activity in rabbit kidney with 20 nM [3H]-D-Ala2-Leu-enkephalin as substrate


J Med Chem 32: 1497-503 (1989)


Article DOI: 10.1021/jm00127a017
BindingDB Entry DOI: 10.7270/Q2610Z9F
More data for this
Ligand-Target Pair