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BDBM50018488 CHEMBL3290356

SMILES: COc1cnc2ccc(=O)n(CCN3CC[C@H](NCc4ccc5OCC(=O)Nc5n4)[C@H](F)C3)c2c1

InChI Key: InChIKey=SQKKZLYGFLBUKP-ZVOYONDMNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50018488   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50018488
PNG
(CHEMBL3290356)
Show SMILES COc1cnc2ccc(=O)n(CCN3CC[C@H](NCc4ccc5OCC(=O)Nc5n4)[C@H](F)C3)c2c1
Show InChI InChI=1/C24H27FN6O4/c1-34-16-10-20-19(27-12-16)3-5-23(33)31(20)9-8-30-7-6-18(17(25)13-30)26-11-15-2-4-21-24(28-15)29-22(32)14-35-21/h2-5,10,12,17-18,26H,6-9,11,13-14H2,1H3,(H,28,29,32)/t17-,18+/s2
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Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp electrophysiological analysis


J Med Chem 57: 4889-905 (2014)


Article DOI: 10.1021/jm500432n
BindingDB Entry DOI: 10.7270/Q2416ZM4
More data for this
Ligand-Target Pair