BDBM50019324 CHEMBL3289398

SMILES CN(C)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O

InChI Key InChIKey=BXYDVWIAGDJBEC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50019324   

TargetDNA-directed RNA polymerase I subunit RPA1(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50019324(CHEMBL3289398)
Affinity DataIC50:  330nMAssay Description:Inhibition of RNA polymerase 1 in human A-375 assessed as RPA194 degradation measured after 4 hrs by Hoechst 33342 staining based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase I subunit RPA1(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50019324(CHEMBL3289398)
Affinity DataIC50:  50nMAssay Description:Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed