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BDBM50019624 1-(2-Ethoxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-yl)-1H-benzoimidazole::CHEMBL594::EMEDASTINE::Emadine

SMILES: CCOCCn1c(nc2ccccc12)N1CCCN(C)CC1

InChI Key: InChIKey=KBUZBQVCBVDWKX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50019624   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50019624
PNG
(1-(2-Ethoxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-yl)...)
Show SMILES CCOCCn1c(nc2ccccc12)N1CCCN(C)CC1
Show InChI InChI=1S/C17H26N4O/c1-3-22-14-13-21-16-8-5-4-7-15(16)18-17(21)20-10-6-9-19(2)11-12-20/h4-5,7-8H,3,6,9-14H2,1-2H3
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PC sid
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Similars

Article
PubMed
n/an/a 6.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of histamine-induced contractions in guinea pig ileum


J Med Chem 29: 1178-83 (1987)


Article DOI: 10.1021/jm00157a010
BindingDB Entry DOI: 10.7270/Q2QR4XPC
More data for this
Ligand-Target Pair