BDBM50020210 CHEMBL3288519::US9914707, I-18

SMILES Nc1n[nH]c2cccc(-c3ccc4c(cccc4c3)C(=O)Nc3cc(Br)cc(Br)c3)c12

InChI Key InChIKey=KDIKNVYPZCVDTG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50020210   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50020210(CHEMBL3288519 | US9914707, I-18)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of VEGFR-2 (unknown origin) expressed in baculovirus expression system using poly (4 Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50020210(CHEMBL3288519 | US9914707, I-18)
Affinity DataIC50:  2.5nMAssay Description:The enzyme reaction substrate Poly(Glu, Tyr)4:1 was diluted with potassium-free PBS (10 mM sodium phosphate buffer, 150 mM NaCl, pH 7.2-7.4) to 20 &#...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50020210(CHEMBL3288519 | US9914707, I-18)
Affinity DataIC50: >100nMAssay Description:Inhibition of VEGFR-2 in HUVEC assessed as inhibition of VEGF (1 to 165)-induced cell proliferation preincubated for 2 hrs followed by VEGF (1 to 165...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed