BDBM50020476 CHEMBL3290148

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(Nc2cccc(NC(=O)CNC(=O)C=C)c2)nc1

InChI Key InChIKey=SMOPKEHQPPXRSH-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50020476   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  13nMAssay Description:Inhibition of Btk in human Ramos cells assessed as inhibition of PLC-gamma2 phosphorylation at Tyr1217 after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of Blk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  0.710nMAssay Description:Inhibition of Bmx (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  7nMAssay Description:Inhibition of EGFR (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  7nMAssay Description:Inhibition of HER2 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50: <4.40nMAssay Description:Inhibition of Btk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Itk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  6.37E+3nMAssay Description:Inhibition of Jak3 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of Rlk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of Tec (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  13nMAssay Description:Inhibition of Btk phosphorylation at Tyr551 in human Ramos cells after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50020476(CHEMBL3290148)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of HER4 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed