BDBM50020476 CHEMBL3290148
SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(Nc2cccc(NC(=O)CNC(=O)C=C)c2)nc1
InChI Key InChIKey=SMOPKEHQPPXRSH-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50020476
Affinity DataIC50: 13nMAssay Description:Inhibition of Btk in human Ramos cells assessed as inhibition of PLC-gamma2 phosphorylation at Tyr1217 after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of Blk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 0.710nMAssay Description:Inhibition of Bmx (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of HER2 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: <4.40nMAssay Description:Inhibition of Btk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Itk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.37E+3nMAssay Description:Inhibition of Jak3 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Rlk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of Tec (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of Btk phosphorylation at Tyr551 in human Ramos cells after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of HER4 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair