BDBM50020712 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene::10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine::3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine::3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine::3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene::5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene::AMITRIPTYLINE::Amitriptylin::CHEMBL629::US20240189287, Compound Amitriptyline

SMILES: [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12

InChI Key: InChIKey=AGLIFTAZEUCEAB-UHFFFAOYSA-N

Data: 81 KI  40 IC50  5 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 133 hits for monomerid = 50020712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.4	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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ATP-binding cassette sub-family C member 3 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transporter (Rat)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H1 receptor (Rat)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Rat)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Histamine H2 receptor (Guinea pig)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Solute carrier family 22 member 1 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.69E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 2 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	8.60E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.20E+6	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+6	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+6	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+6	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 7 subunit alpha (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Rat)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Rat)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Albumin (Rat)	BDBM50020712 (CHEMBL629 | Amitriptylin | 10,11-dihydro-N,N-dimet...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.34E+5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair