BDBM50021718 CHEMBL3298678

SMILES OC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1

InChI Key InChIKey=OJRJASQFNLOAKZ-LJQANCHMSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50021718   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataKi:  0.600nMAssay Description:Inhibition of 6-His tagged human ERK2 expressed in Escherichia coli measured over 30 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataIC50:  25nMAssay Description:Inhibition of ERK2 in human HepG2 cells assessed as P90RSK phosphorylation at Ser380 after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataIC50:  10nMAssay Description:Inhibition of Cdk2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021718(CHEMBL3298678)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed