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BDBM50022395 6-methoxyspiro[3,4-dihydro-2H-chromene-4,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione::CHEMBL79430

SMILES: COc1ccc2OCCC3(NC(=O)NC3=O)c2c1

InChI Key: InChIKey=PFCZBBPQBWEUOH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022395   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022395
PNG
(6-methoxyspiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Show SMILES COc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C12H12N2O4/c1-17-7-2-3-9-8(6-7)12(4-5-18-9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair