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BDBM50022397 8-chloro-6-phenylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione::CHEMBL81029

SMILES: Clc1cc(cc2c1OCCC21NC(=O)NC1=O)-c1ccccc1

InChI Key: InChIKey=BGBMHFWLXXUTGK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022397   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022397
PNG
(8-chloro-6-phenylspiro[3,4-dihydro-2H-chromene-4,4...)
Show SMILES Clc1cc(cc2c1OCCC21NC(=O)NC1=O)-c1ccccc1
Show InChI InChI=1S/C17H13ClN2O3/c18-13-9-11(10-4-2-1-3-5-10)8-12-14(13)23-7-6-17(12)15(21)19-16(22)20-17/h1-5,8-9H,6-7H2,(H2,19,20,21,22)
PDB

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PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair