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BDBM50022405 2',5'-dioxospiro[3,4-dihydro-2H-chromene-4,4'-(tetrahydro-1'H-imidazole)]-6-carboxamide(1/8H2O)::CHEMBL82548

SMILES: NC(=O)c1ccc2OCCC3(NC(=O)NC3=O)c2c1

InChI Key: InChIKey=NJWYFNDPTHFSEA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022405   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022405
PNG
(2',5'-dioxospiro[3,4-dihydro-2H-chromene-4,4'-(tet...)
Show SMILES NC(=O)c1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C12H11N3O4/c13-9(16)6-1-2-8-7(5-6)12(3-4-19-8)10(17)14-11(18)15-12/h1-2,5H,3-4H2,(H2,13,16)(H2,14,15,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair